| 2021-10-22 | 112 - 123 | CLEVELAND CAVALIERS v. CHARLOTTE HORNETS | * | 28:04 | 15 | 5 / 12 | 2 / 6 | 3 / 6 | 2 / 2 | 1 | 1 | 10 | 2 | 0 | 6 | 1 | 28 |
| 2021-10-23 | 101 - 95 | CLEVELAND CAVALIERS v. ATLANTA HAWKS | * | 35:05 | 23 | 9 / 15 | 6 / 8 | 3 / 7 | 2 / 2 | 6 | 0 | 8 | 1 | 0 | 3 | 3 | 35 |
| 2021-10-25 | 87 - 99 | CLEVELAND CAVALIERS @ DENVER NUGGETS | | 24:52 | 7 | 2 / 10 | 2 / 7 | 0 / 3 | 3 / 4 | 4 | 0 | 8 | 1 | 1 | 2 | 5 | 12 |
| 2021-10-27 | 79 - 92 | CLEVELAND CAVALIERS @ LOS ANGELES CLIPPERS | | 27:56 | 15 | 6 / 13 | 6 / 10 | 0 / 3 | 3 / 3 | 3 | 0 | 3 | 0 | 0 | 4 | 3 | 18 |
| 2021-10-29 | 113 - 101 | CLEVELAND CAVALIERS @ LOS ANGELES LAKERS | | 31:35 | 18 | 6 / 15 | 3 / 7 | 3 / 8 | 3 / 3 | 3 | 3 | 4 | 3 | 0 | 3 | 2 | 25 |
| 2021-10-30 | 101 - 92 | CLEVELAND CAVALIERS @ PHOENIX SUNS | | 25:00 | 8 | 3 / 15 | 1 / 9 | 2 / 6 | 0 / 0 | 4 | 0 | 3 | 1 | 0 | 2 | 1 | 6 |
| 2021-11-01 | 110 - 113 | CLEVELAND CAVALIERS @ CHARLOTTE HORNETS | | 24:49 | 5 | 1 / 7 | 0 / 5 | 1 / 2 | 2 / 4 | 1 | 0 | 8 | 2 | 1 | 3 | 1 | 10 |
| 2021-11-03 | 107 - 104 | CLEVELAND CAVALIERS v. PORTLAND TRAIL BLAZERS | | 31:09 | 0 | 0 / 7 | 0 / 3 | 0 / 4 | 0 / 0 | 3 | 0 | 7 | 1 | 0 | 1 | 1 | 5 |
| 2021-11-05 | 101 - 102 | CLEVELAND CAVALIERS @ TORONTO RAPTORS | | 22:11 | 11 | 4 / 8 | 3 / 7 | 1 / 1 | 2 / 2 | 3 | 2 | 4 | 0 | 0 | 3 | 5 | 19 |
| 2021-11-07 | 109 - 126 | CLEVELAND CAVALIERS @ NEW YORK KNICKS | | 31:20 | 37 | 13 / 19 | 5 / 10 | 8 / 9 | 3 / 3 | 3 | 0 | 10 | 1 | 0 | 4 | 1 | 49 |
| 2021-11-10 | 94 - 97 | CLEVELAND CAVALIERS v. WASHINGTON WIZARDS | | 27:40 | 20 | 6 / 15 | 5 / 10 | 1 / 5 | 7 / 8 | 5 | 0 | 5 | 2 | 0 | 3 | 1 | 25 |
| 2021-11-12 | 98 - 78 | CLEVELAND CAVALIERS v. DETROIT PISTONS | | 27:10 | 5 | 2 / 9 | 1 / 4 | 1 / 5 | 0 / 0 | 1 | 0 | 9 | 5 | 0 | 3 | 0 | 16 |
| 2021-11-13 | 91 - 89 | CLEVELAND CAVALIERS v. BOSTON CELTICS | | 32:38 | 16 | 4 / 17 | 2 / 9 | 2 / 8 | 6 / 6 | 4 | 1 | 7 | 1 | 0 | 1 | 4 | 17 |
| 2021-11-15 | 92 - 98 | CLEVELAND CAVALIERS v. BOSTON CELTICS | * | 37:13 | 28 | 9 / 20 | 5 / 12 | 4 / 8 | 6 / 7 | 6 | 0 | 2 | 0 | 0 | 3 | 2 | 27 |
| 2021-11-17 | 109 - 99 | CLEVELAND CAVALIERS @ BROOKLYN NETS | * | 33:15 | 25 | 8 / 17 | 5 / 7 | 3 / 10 | 6 / 6 | 4 | 0 | 5 | 0 | 0 | 5 | 2 | 30 |
| 2021-11-18 | 89 - 104 | CLEVELAND CAVALIERS v. GOLDEN STATE WARRIORS | * | 37:37 | 10 | 4 / 15 | 3 / 10 | 1 / 5 | 1 / 2 | 0 | 0 | 5 | 2 | 0 | 5 | 1 | 10 |
| 2021-11-22 | 112 - 117 | CLEVELAND CAVALIERS v. BROOKLYN NETS | | 29:27 | 16 | 4 / 12 | 1 / 4 | 3 / 8 | 5 / 5 | 5 | 2 | 5 | 0 | 1 | 4 | 3 | 23 |
| 2021-11-24 | 115 - 120 | CLEVELAND CAVALIERS v. PHOENIX SUNS | | 29:10 | 15 | 5 / 20 | 3 / 12 | 2 / 8 | 3 / 6 | 4 | 0 | 5 | 1 | 0 | 2 | 3 | 9 |
| 2021-11-27 | 105 - 92 | CLEVELAND CAVALIERS v. ORLANDO MAGIC | | 26:47 | 5 | 1 / 6 | 0 / 1 | 1 / 5 | 2 / 2 | 4 | 0 | 8 | 1 | 0 | 3 | 4 | 16 |
| 2021-11-29 | 96 - 114 | CLEVELAND CAVALIERS @ DALLAS MAVERICKS | | 28:03 | 7 | 3 / 11 | 2 / 10 | 1 / 1 | 0 / 0 | 7 | 0 | 6 | 1 | 0 | 2 | 3 | 15 |
| 2021-12-01 | 85 - 111 | CLEVELAND CAVALIERS @ MIAMI HEAT | | 25:49 | 6 | 1 / 5 | 1 / 2 | 0 / 3 | 4 / 5 | 4 | 1 | 6 | 2 | 0 | 3 | 1 | 17 |
| 2021-12-03 | 101 - 116 | CLEVELAND CAVALIERS @ WASHINGTON WIZARDS | | 28:51 | 7 | 3 / 11 | 2 / 8 | 1 / 3 | 0 / 1 | 4 | 0 | 6 | 0 | 0 | 0 | 1 | 8 |
| 2021-12-05 | 108 - 109 | CLEVELAND CAVALIERS v. UTAH JAZZ | | 30:42 | 15 | 6 / 11 | 4 / 5 | 2 / 6 | 1 / 2 | 4 | 0 | 2 | 1 | 1 | 1 | 1 | 16 |
| 2021-12-06 | 112 - 104 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | | 27:40 | 7 | 2 / 9 | 1 / 5 | 1 / 4 | 2 / 2 | 3 | 1 | 9 | 0 | 0 | 0 | 3 | 13 |
| 2021-12-08 | 115 - 92 | CLEVELAND CAVALIERS v. CHICAGO BULLS | | 23:10 | 11 | 3 / 7 | 3 / 6 | 0 / 1 | 5 / 5 | 4 | 0 | 9 | 1 | 0 | 1 | 2 | 22 |
| 2021-12-10 | 106 - 123 | CLEVELAND CAVALIERS @ MINNESOTA TIMBERWOLVES | | 22:57 | 6 | 2 / 9 | 1 / 5 | 1 / 4 | 1 / 2 | 3 | 1 | 8 | 0 | 0 | 3 | 3 | 13 |
| 2021-12-11 | 117 - 103 | CLEVELAND CAVALIERS v. SACRAMENTO KINGS | | 26:21 | 15 | 4 / 9 | 2 / 6 | 2 / 3 | 5 / 6 | 2 | 0 | 3 | 3 | 0 | 4 | 5 | 21 |
| 2021-12-13 | 105 - 94 | CLEVELAND CAVALIERS v. MIAMI HEAT | | 27:40 | 7 | 3 / 9 | 2 / 5 | 1 / 4 | 0 / 0 | 3 | 0 | 7 | 1 | 0 | 1 | 3 | 13 |
| 2021-12-15 | 124 - 89 | CLEVELAND CAVALIERS v. HOUSTON ROCKETS | | 21:18 | 7 | 2 / 6 | 2 / 3 | 0 / 3 | 3 / 3 | 2 | 0 | 12 | 4 | 0 | 2 | 1 | 23 |
| 2021-12-18 | 90 - 119 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | | 29:10 | 15 | 6 / 12 | 4 / 6 | 2 / 6 | 1 / 1 | 5 | 0 | 10 | 3 | 1 | 4 | 2 | 30 |
| 2021-12-22 | 111 - 101 | CLEVELAND CAVALIERS @ BOSTON CELTICS | * | 30:33 | 8 | 2 / 12 | 1 / 7 | 1 / 5 | 3 / 4 | 4 | 1 | 6 | 3 | 0 | 4 | 1 | 15 |
| 2021-12-26 | 144 - 99 | CLEVELAND CAVALIERS v. TORONTO RAPTORS | * | 23:20 | 16 | 6 / 13 | 4 / 7 | 2 / 6 | 2 / 2 | 2 | 0 | 6 | 3 | 0 | 2 | 2 | 22 |
| 2021-12-28 | 108 - 104 | CLEVELAND CAVALIERS @ NEW ORLEANS PELICANS | * | 36:46 | 27 | 10 / 25 | 7 / 18 | 3 / 7 | 4 / 4 | 11 | 2 | 9 | 2 | 2 | 1 | 1 | 35 |
