| 2021-10-22 | 112 - 123 | CLEVELAND CAVALIERS v. CHARLOTTE HORNETS | * | 34:24 | 13 | 5 / 11 | 3 / 6 | 2 / 5 | 1 / 2 | 4 | 1 | 2 | 0 | 0 | 0 | 1 | 13 |
| 2021-10-23 | 101 - 95 | CLEVELAND CAVALIERS v. ATLANTA HAWKS | * | 31:42 | 12 | 3 / 15 | 2 / 9 | 1 / 6 | 5 / 6 | 5 | 3 | 2 | 1 | 2 | 0 | 0 | 8 |
| 2021-10-25 | 87 - 99 | CLEVELAND CAVALIERS @ DENVER NUGGETS | * | 27:29 | 12 | 4 / 12 | 2 / 4 | 2 / 8 | 2 / 2 | 4 | 0 | 2 | 4 | 1 | 1 | 1 | 14 |
| 2021-10-27 | 79 - 92 | CLEVELAND CAVALIERS @ LOS ANGELES CLIPPERS | * | 28:35 | 7 | 2 / 7 | 2 / 3 | 0 / 4 | 3 / 3 | 8 | 1 | 1 | 1 | 0 | 3 | 1 | 16 |
| 2021-10-29 | 113 - 101 | CLEVELAND CAVALIERS @ LOS ANGELES LAKERS | * | 31:58 | 17 | 7 / 14 | 4 / 6 | 3 / 8 | 0 / 0 | 3 | 0 | 1 | 0 | 0 | 0 | 3 | 14 |
| 2021-10-30 | 101 - 92 | CLEVELAND CAVALIERS @ PHOENIX SUNS | * | 25:09 | 11 | 3 / 5 | 1 / 1 | 2 / 4 | 3 / 3 | 1 | 0 | 2 | 1 | 2 | 0 | 2 | 11 |
| 2021-11-01 | 110 - 113 | CLEVELAND CAVALIERS @ CHARLOTTE HORNETS | * | 35:03 | 21 | 7 / 19 | 5 / 11 | 2 / 8 | 5 / 6 | 5 | 3 | 0 | 2 | 2 | 2 | 2 | 18 |
| 2021-11-22 | 112 - 117 | CLEVELAND CAVALIERS v. BROOKLYN NETS | * | 30:49 | 22 | 7 / 17 | 4 / 8 | 3 / 9 | 5 / 5 | 6 | 2 | 1 | 0 | 1 | 1 | 1 | 21 |
| 2021-11-24 | 115 - 120 | CLEVELAND CAVALIERS v. PHOENIX SUNS | * | 35:48 | 14 | 5 / 13 | 3 / 6 | 2 / 7 | 2 / 2 | 9 | 2 | 0 | 1 | 0 | 1 | 2 | 19 |
| 2021-11-27 | 105 - 92 | CLEVELAND CAVALIERS v. ORLANDO MAGIC | * | 32:18 | 20 | 8 / 13 | 4 / 5 | 4 / 8 | 0 / 0 | 3 | 2 | 0 | 0 | 0 | 1 | 0 | 21 |
| 2021-11-29 | 96 - 114 | CLEVELAND CAVALIERS @ DALLAS MAVERICKS | * | 33:18 | 24 | 9 / 15 | 4 / 6 | 5 / 9 | 1 / 1 | 7 | 1 | 2 | 1 | 0 | 0 | 4 | 29 |
| 2021-12-01 | 85 - 111 | CLEVELAND CAVALIERS @ MIAMI HEAT | * | 26:16 | 6 | 2 / 8 | 1 / 3 | 1 / 5 | 1 / 2 | 1 | 0 | 0 | 1 | 0 | 1 | 2 | 2 |
| 2021-12-03 | 101 - 116 | CLEVELAND CAVALIERS @ WASHINGTON WIZARDS | * | 36:04 | 15 | 5 / 14 | 1 / 2 | 4 / 12 | 1 / 1 | 5 | 1 | 2 | 0 | 0 | 0 | 0 | 14 |
| 2021-12-05 | 108 - 109 | CLEVELAND CAVALIERS v. UTAH JAZZ | * | 34:39 | 9 | 4 / 10 | 3 / 5 | 1 / 5 | 0 / 1 | 3 | 2 | 0 | 0 | 0 | 0 | 1 | 7 |
| 2021-12-06 | 112 - 104 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | * | 34:25 | 20 | 7 / 15 | 3 / 6 | 4 / 9 | 2 / 2 | 6 | 1 | 2 | 0 | 1 | 0 | 3 | 20 |
| 2021-12-08 | 115 - 92 | CLEVELAND CAVALIERS v. CHICAGO BULLS | * | 27:13 | 14 | 5 / 8 | 3 / 4 | 2 / 4 | 2 / 2 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 14 |
| 2021-12-10 | 106 - 123 | CLEVELAND CAVALIERS @ MINNESOTA TIMBERWOLVES | * | 21:39 | 19 | 7 / 8 | 3 / 3 | 4 / 5 | 1 / 2 | 2 | 0 | 2 | 2 | 0 | 1 | 2 | 24 |
| 2021-12-11 | 117 - 103 | CLEVELAND CAVALIERS v. SACRAMENTO KINGS | * | 26:09 | 3 | 1 / 8 | 1 / 5 | 0 / 3 | 1 / 2 | 2 | 0 | 2 | 2 | 0 | 2 | 6 | 3 |
| 2021-12-13 | 105 - 94 | CLEVELAND CAVALIERS v. MIAMI HEAT | * | 31:32 | 12 | 5 / 13 | 3 / 6 | 2 / 7 | 0 / 0 | 3 | 1 | 2 | 0 | 0 | 0 | 1 | 10 |
| 2021-12-15 | 124 - 89 | CLEVELAND CAVALIERS v. HOUSTON ROCKETS | * | 18:58 | 12 | 5 / 10 | 3 / 5 | 2 / 5 | 0 / 0 | 2 | 0 | 1 | 0 | 0 | 1 | 1 | 11 |
| 2021-12-18 | 90 - 119 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | * | 29:10 | 8 | 3 / 14 | 3 / 7 | 0 / 7 | 2 / 3 | 1 | 1 | 2 | 0 | 0 | 2 | 1 | 2 |
| 2021-12-22 | 111 - 101 | CLEVELAND CAVALIERS @ BOSTON CELTICS | * | 32:57 | 7 | 2 / 12 | 2 / 7 | 0 / 5 | 3 / 3 | 6 | 3 | 0 | 0 | 1 | 1 | 1 | 6 |
| 2021-12-26 | 144 - 99 | CLEVELAND CAVALIERS v. TORONTO RAPTORS | * | 22:09 | 20 | 9 / 13 | 8 / 10 | 1 / 3 | 1 / 1 | 5 | 2 | 1 | 0 | 1 | 2 | 2 | 25 |
| 2021-12-28 | 108 - 104 | CLEVELAND CAVALIERS @ NEW ORLEANS PELICANS | * | 30:30 | 14 | 6 / 15 | 6 / 11 | 0 / 4 | 2 / 2 | 4 | 1 | 2 | 2 | 0 | 1 | 4 | 15 |
| 2021-12-30 | 110 - 93 | CLEVELAND CAVALIERS @ WASHINGTON WIZARDS | * | 26:14 | 11 | 4 / 10 | 3 / 6 | 1 / 4 | 2 / 2 | 6 | 2 | 4 | 1 | 1 | 2 | 3 | 19 |
| 2021-12-31 | 118 - 121 | CLEVELAND CAVALIERS v. ATLANTA HAWKS | * | 30:33 | 8 | 4 / 10 | 4 / 8 | 0 / 2 | 0 / 0 | 5 | 0 | 2 | 0 | 1 | 2 | 2 | 10 |
| 2022-01-02 | 108 - 104 | CLEVELAND CAVALIERS v. INDIANA PACERS | * | 33:37 | 12 | 5 / 12 | 3 / 6 | 2 / 6 | 0 / 0 | 4 | 2 | 2 | 0 | 1 | 0 | 2 | 12 |
| 2022-01-04 | 106 - 110 | CLEVELAND CAVALIERS v. MEMPHIS GRIZZLIES | * | 36:19 | 13 | 5 / 11 | 4 / 6 | 1 / 5 | 2 / 2 | 6 | 1 | 5 | 0 | 1 | 1 | 3 | 19 |
| 2022-01-07 | 101 - 114 | CLEVELAND CAVALIERS @ PORTLAND TRAIL BLAZERS | * | 33:24 | 15 | 4 / 9 | 2 / 3 | 2 / 6 | 5 / 6 | 1 | 0 | 5 | 1 | 1 | 0 | 2 | 15 |
| 2022-01-09 | 96 - 82 | CLEVELAND CAVALIERS @ GOLDEN STATE WARRIORS | * | 29:06 | 9 | 2 / 6 | 1 / 3 | 1 / 3 | 4 / 4 | 5 | 1 | 2 | 1 | 0 | 0 | 1 | 14 |
| 2022-01-10 | 108 - 109 | CLEVELAND CAVALIERS @ SACRAMENTO KINGS | * | 32:51 | 15 | 6 / 14 | 3 / 6 | 3 / 8 | 0 / 0 | 4 | 1 | 1 | 0 | 1 | 0 | 2 | 12 |
| 2022-01-12 | 91 - 111 | CLEVELAND CAVALIERS @ UTAH JAZZ | * | 35:08 | 20 | 8 / 11 | 4 / 6 | 4 / 5 | 0 / 0 | 3 | 3 | 1 | 0 | 1 | 0 | 2 | 23 |
| 2022-01-14 | 109 - 114 | CLEVELAND CAVALIERS @ SAN ANTONIO SPURS | * | 33:32 | 8 | 4 / 5 | 4 / 4 | 0 / 1 | 0 / 0 | 5 | 1 | 0 | 1 | 1 | 1 | 2 | 14 |
| 2022-01-15 | 102 - 107 | CLEVELAND CAVALIERS @ OKLAHOMA CITY THUNDER | * | 31:51 | 12 | 4 / 10 | 2 / 4 | 2 / 6 | 2 / 2 | 5 | 0 | 1 | 4 | 0 | 0 | 2 | 16 |
| 2022-01-17 | 114 - 107 | CLEVELAND CAVALIERS v. BROOKLYN NETS | * | 29:46 | 14 | 5 / 12 | 1 / 3 | 4 / 9 | 0 / 0 | 6 | 0 | 1 | 1 | 0 | 3 | 2 | 18 |
| 2022-01-19 | 117 - 104 | CLEVELAND CAVALIERS @ CHICAGO BULLS | * | 32:33 | 28 | 9 / 14 | 4 / 5 | 5 / 9 | 5 / 6 | 6 | 1 | 0 | 1 | 1 | 0 | 2 | 29 |
| 2022-01-22 | 94 - 87 | CLEVELAND CAVALIERS v. OKLAHOMA CITY THUNDER | * | 13:00 | 9 | 3 / 4 | 0 / 0 | 3 / 4 | 0 / 0 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 9 |
| 2022-02-24 | 106 - 103 | CLEVELAND CAVALIERS @ DETROIT PISTONS | * | 27:43 | 22 | 6 / 16 | 4 / 9 | 2 / 7 | 8 / 10 | 4 | 2 | 1 | 0 | 1 | 0 | 4 | 16 |
| 2022-02-26 | 92 - 86 | CLEVELAND CAVALIERS v. WASHINGTON WIZARDS | * | 34:33 | 23 | 6 / 18 | 0 / 9 | 6 / 9 | 5 / 6 | 6 | 0 | 1 | 0 | 1 | 1 | 0 | 17 |
| 2022-02-28 | 122 - 127 | CLEVELAND CAVALIERS v. MINNESOTA TIMBERWOLVES | * | 35:04 | 10 | 2 / 7 | 1 / 1 | 1 / 6 | 5 / 6 | 4 | 0 | 1 | 0 | 0 | 5 | 2 | 14 |
| 2022-03-02 | 98 - 119 | CLEVELAND CAVALIERS v. CHARLOTTE HORNETS | * | 30:47 | 12 | 3 / 10 | 1 / 4 | 2 / 6 | 4 / 4 | 5 | 0 | 3 | 2 | 0 | 1 | 0 | 16 |
| 2022-03-04 | 125 - 119 | CLEVELAND CAVALIERS @ PHILADELPHIA 76ERS | * | 17:32 | 6 | 3 / 7 | 3 / 6 | 0 / 1 | 0 / 0 | 4 | 3 | 0 | 1 | 0 | 1 | 4 | 11 |
| 2022-03-06 | 104 - 96 | CLEVELAND CAVALIERS v. TORONTO RAPTORS | * | 37:43 | 22 | 8 / 18 | 5 / 6 | 3 / 12 | 3 / 4 | 12 | 0 | 0 | 0 | 1 | 1 | 0 | 23 |
| 2022-03-08 | 124 - 127 | CLEVELAND CAVALIERS @ INDIANA PACERS | * | 30:09 | 21 | 8 / 14 | 7 / 9 | 1 / 5 | 4 / 4 | 2 | 3 | 1 | 1 | 1 | 0 | 3 | 21 |
| 2022-03-11 | 117 - 105 | CLEVELAND CAVALIERS @ MIAMI HEAT | * | 31:49 | 15 | 6 / 12 | 4 / 6 | 2 / 6 | 1 / 1 | 4 | 0 | 1 | 1 | 1 | 1 | 2 | 15 |
| 2022-03-16 | 114 - 118 | CLEVELAND CAVALIERS v. PHILADELPHIA 76ERS | * | 33:11 | 13 | 4 / 9 | 2 / 3 | 2 / 6 | 3 / 4 | 4 | 0 | 2 | 2 | 0 | 0 | 2 | 15 |
| 2022-03-19 | 113 - 109 | CLEVELAND CAVALIERS v. DETROIT PISTONS | * | 32:49 | 8 | 3 / 8 | 2 / 4 | 1 / 4 | 1 / 2 | 4 | 0 | 2 | 0 | 0 | 1 | 2 | 9 |
| 2022-03-21 | 120 - 131 | CLEVELAND CAVALIERS v. LOS ANGELES LAKERS | * | 37:18 | 18 | 6 / 12 | 2 / 2 | 4 / 10 | 2 / 2 | 8 | 1 | 1 | 0 | 0 | 0 | 2 | 22 |
| 2022-03-24 | 117 - 104 | CLEVELAND CAVALIERS @ TORONTO RAPTORS | * | 36:07 | 20 | 6 / 10 | 4 / 4 | 2 / 6 | 6 / 6 | 4 | 1 | 1 | 1 | 0 | 1 | 2 | 24 |
| 2022-03-26 | 94 - 98 | CLEVELAND CAVALIERS v. CHICAGO BULLS | * | 32:22 | 14 | 5 / 13 | 4 / 6 | 1 / 7 | 3 / 4 | 6 | 3 | 2 | 2 | 1 | 2 | 6 | 19 |