| 2021-10-22 | 112 - 123 | CLEVELAND CAVALIERS v. CHARLOTTE HORNETS | | 23:40 | 6 | 2 / 8 | 2 / 5 | 0 / 3 | 2 / 2 | 10 | 1 | 4 | 1 | 1 | 1 | 1 | 16 |
| 2021-10-23 | 101 - 95 | CLEVELAND CAVALIERS v. ATLANTA HAWKS | | 23:45 | 12 | 3 / 7 | 2 / 4 | 1 / 3 | 5 / 6 | 4 | 2 | 3 | 0 | 0 | 0 | 0 | 16 |
| 2021-10-25 | 87 - 99 | CLEVELAND CAVALIERS @ DENVER NUGGETS | | 20:55 | 22 | 8 / 13 | 7 / 9 | 1 / 4 | 5 / 5 | 5 | 1 | 0 | 0 | 0 | 1 | 0 | 24 |
| 2021-10-27 | 79 - 92 | CLEVELAND CAVALIERS @ LOS ANGELES CLIPPERS | | 23:40 | 10 | 2 / 9 | 1 / 6 | 1 / 3 | 5 / 6 | 6 | 4 | 1 | 1 | 0 | 1 | 0 | 15 |
| 2021-10-29 | 113 - 101 | CLEVELAND CAVALIERS @ LOS ANGELES LAKERS | | 16:00 | 4 | 2 / 7 | 2 / 4 | 0 / 3 | 0 / 0 | 3 | 0 | 2 | 0 | 0 | 1 | 1 | 5 |
| 2021-10-30 | 101 - 92 | CLEVELAND CAVALIERS @ PHOENIX SUNS | | 19:33 | 11 | 4 / 12 | 2 / 6 | 2 / 6 | 1 / 1 | 11 | 1 | 2 | 0 | 0 | 1 | 3 | 18 |
| 2021-11-17 | 109 - 99 | CLEVELAND CAVALIERS @ BROOKLYN NETS | | 21:26 | 11 | 4 / 10 | 3 / 5 | 1 / 5 | 2 / 2 | 8 | 1 | 2 | 0 | 0 | 2 | 1 | 18 |
| 2021-11-18 | 89 - 104 | CLEVELAND CAVALIERS v. GOLDEN STATE WARRIORS | | 21:32 | 17 | 5 / 12 | 1 / 2 | 4 / 10 | 3 / 3 | 6 | 1 | 2 | 0 | 0 | 1 | 1 | 20 |
| 2021-11-22 | 112 - 117 | CLEVELAND CAVALIERS v. BROOKLYN NETS | | 17:08 | 8 | 3 / 8 | 1 / 3 | 2 / 5 | 0 / 0 | 11 | 1 | 0 | 0 | 1 | 0 | 1 | 14 |
| 2021-11-24 | 115 - 120 | CLEVELAND CAVALIERS v. PHOENIX SUNS | | 22:23 | 14 | 5 / 9 | 3 / 4 | 2 / 5 | 2 / 2 | 6 | 2 | 1 | 0 | 0 | 1 | 3 | 20 |
| 2021-11-27 | 105 - 92 | CLEVELAND CAVALIERS v. ORLANDO MAGIC | | 18:52 | 5 | 2 / 8 | 1 / 3 | 1 / 5 | 0 / 0 | 7 | 0 | 1 | 0 | 1 | 1 | 3 | 7 |
| 2021-11-29 | 96 - 114 | CLEVELAND CAVALIERS @ DALLAS MAVERICKS | | 17:27 | 10 | 3 / 4 | 1 / 2 | 2 / 2 | 2 / 2 | 4 | 1 | 3 | 0 | 0 | 2 | 1 | 19 |
| 2021-12-01 | 85 - 111 | CLEVELAND CAVALIERS @ MIAMI HEAT | | 21:04 | 22 | 6 / 9 | 0 / 1 | 6 / 8 | 4 / 4 | 6 | 0 | 3 | 2 | 1 | 1 | 1 | 30 |
| 2021-12-03 | 101 - 116 | CLEVELAND CAVALIERS @ WASHINGTON WIZARDS | | 17:34 | 13 | 4 / 9 | 3 / 5 | 1 / 4 | 4 / 4 | 5 | 4 | 2 | 0 | 0 | 0 | 0 | 19 |
| 2021-12-05 | 108 - 109 | CLEVELAND CAVALIERS v. UTAH JAZZ | | 19:02 | 3 | 1 / 6 | 0 / 2 | 1 / 4 | 0 / 0 | 1 | 1 | 1 | 0 | 0 | 2 | 0 | 3 |
| 2021-12-06 | 112 - 104 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | | 18:59 | 15 | 5 / 11 | 0 / 0 | 5 / 11 | 0 / 0 | 4 | 0 | 3 | 0 | 0 | 1 | 1 | 17 |
| 2021-12-08 | 115 - 92 | CLEVELAND CAVALIERS v. CHICAGO BULLS | | 19:58 | 11 | 4 / 11 | 1 / 5 | 3 / 6 | 0 / 0 | 5 | 0 | 1 | 0 | 0 | 2 | 1 | 12 |
| 2021-12-10 | 106 - 123 | CLEVELAND CAVALIERS @ MINNESOTA TIMBERWOLVES | | 22:50 | 18 | 4 / 10 | 1 / 3 | 3 / 7 | 7 / 7 | 13 | 0 | 4 | 1 | 1 | 2 | 0 | 31 |
| 2021-12-11 | 117 - 103 | CLEVELAND CAVALIERS v. SACRAMENTO KINGS | | 13:35 | 11 | 4 / 7 | 1 / 2 | 3 / 5 | 0 / 0 | 4 | 0 | 1 | 0 | 0 | 1 | 3 | 14 |
| 2021-12-13 | 105 - 94 | CLEVELAND CAVALIERS v. MIAMI HEAT | | 23:49 | 23 | 6 / 10 | 1 / 2 | 5 / 8 | 6 / 6 | 8 | 1 | 1 | 0 | 0 | 2 | 2 | 31 |
| 2021-12-15 | 124 - 89 | CLEVELAND CAVALIERS v. HOUSTON ROCKETS | | 15:20 | 15 | 4 / 6 | 1 / 1 | 3 / 5 | 4 / 4 | 6 | 0 | 0 | 0 | 1 | 2 | 2 | 20 |
| 2021-12-18 | 90 - 119 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | | 23:03 | 15 | 4 / 10 | 2 / 2 | 2 / 8 | 5 / 5 | 7 | 0 | 4 | 1 | 0 | 0 | 0 | 21 |
| 2021-12-22 | 111 - 101 | CLEVELAND CAVALIERS @ BOSTON CELTICS | | 22:56 | 18 | 6 / 13 | 5 / 8 | 1 / 5 | 5 / 7 | 7 | 5 | 3 | 1 | 0 | 1 | 4 | 26 |
| 2021-12-26 | 144 - 99 | CLEVELAND CAVALIERS v. TORONTO RAPTORS | * | 18:17 | 22 | 7 / 12 | 1 / 3 | 6 / 9 | 2 / 2 | 8 | 1 | 2 | 1 | 0 | 1 | 0 | 30 |
| 2021-12-28 | 108 - 104 | CLEVELAND CAVALIERS @ NEW ORLEANS PELICANS | | 32:05 | 24 | 7 / 14 | 0 / 2 | 7 / 12 | 3 / 4 | 2 | 2 | 3 | 1 | 0 | 1 | 0 | 25 |
| 2021-12-30 | 110 - 93 | CLEVELAND CAVALIERS @ WASHINGTON WIZARDS | * | 29:27 | 24 | 7 / 15 | 3 / 5 | 4 / 10 | 6 / 8 | 11 | 0 | 1 | 1 | 0 | 2 | 1 | 29 |
| 2021-12-31 | 118 - 121 | CLEVELAND CAVALIERS v. ATLANTA HAWKS | | 29:48 | 35 | 10 / 18 | 3 / 4 | 7 / 14 | 8 / 10 | 10 | 1 | 4 | 0 | 0 | 1 | 0 | 41 |
| 2022-01-02 | 108 - 104 | CLEVELAND CAVALIERS v. INDIANA PACERS | | 29:10 | 20 | 6 / 13 | 3 / 7 | 3 / 6 | 5 / 5 | 6 | 2 | 4 | 1 | 0 | 1 | 2 | 27 |
| 2022-01-04 | 106 - 110 | CLEVELAND CAVALIERS v. MEMPHIS GRIZZLIES | | 28:52 | 18 | 6 / 18 | 2 / 7 | 4 / 11 | 2 / 3 | 6 | 3 | 2 | 0 | 0 | 2 | 0 | 18 |
| 2022-01-07 | 101 - 114 | CLEVELAND CAVALIERS @ PORTLAND TRAIL BLAZERS | | 26:32 | 8 | 3 / 9 | 1 / 3 | 2 / 6 | 0 / 2 | 6 | 1 | 2 | 0 | 0 | 1 | 1 | 10 |
| 2022-01-09 | 96 - 82 | CLEVELAND CAVALIERS @ GOLDEN STATE WARRIORS | | 14:06 | 2 | 1 / 7 | 1 / 3 | 0 / 4 | 0 / 0 | 6 | 1 | 1 | 0 | 0 | 2 | 0 | 6 |
| 2022-01-10 | 108 - 109 | CLEVELAND CAVALIERS @ SACRAMENTO KINGS | | 20:35 | 18 | 5 / 13 | 3 / 5 | 2 / 8 | 6 / 7 | 3 | 0 | 2 | 0 | 2 | 2 | 0 | 14 |
| 2022-01-12 | 91 - 111 | CLEVELAND CAVALIERS @ UTAH JAZZ | | 20:54 | 16 | 5 / 10 | 3 / 5 | 2 / 5 | 4 / 4 | 7 | 0 | 1 | 0 | 0 | 2 | 0 | 21 |
| 2022-01-14 | 109 - 114 | CLEVELAND CAVALIERS @ SAN ANTONIO SPURS | | 16:25 | 7 | 3 / 7 | 2 / 4 | 1 / 3 | 0 / 0 | 3 | 1 | 1 | 0 | 0 | 0 | 1 | 8 |
| 2022-01-15 | 102 - 107 | CLEVELAND CAVALIERS @ OKLAHOMA CITY THUNDER | | 21:08 | 13 | 5 / 11 | 2 / 3 | 3 / 8 | 0 / 0 | 2 | 0 | 1 | 0 | 0 | 1 | 0 | 11 |
| 2022-01-17 | 114 - 107 | CLEVELAND CAVALIERS v. BROOKLYN NETS | | 19:53 | 14 | 3 / 8 | 2 / 4 | 1 / 4 | 7 / 7 | 4 | 1 | 5 | 0 | 0 | 1 | 0 | 20 |
| 2022-01-19 | 117 - 104 | CLEVELAND CAVALIERS @ CHICAGO BULLS | | 20:58 | 13 | 5 / 10 | 4 / 6 | 1 / 4 | 2 / 3 | 6 | 2 | 4 | 0 | 0 | 2 | 0 | 21 |
| 2022-01-22 | 94 - 87 | CLEVELAND CAVALIERS v. OKLAHOMA CITY THUNDER | | 22:44 | 6 | 1 / 4 | 1 / 1 | 0 / 3 | 4 / 7 | 6 | 0 | 2 | 0 | 0 | 1 | 1 | 9 |
| 2022-01-24 | 95 - 93 | CLEVELAND CAVALIERS v. NEW YORK KNICKS | | 23:57 | 20 | 6 / 12 | 0 / 0 | 6 / 12 | 2 / 2 | 11 | 0 | 3 | 1 | 0 | 3 | 2 | 32 |
| 2022-01-26 | 115 - 99 | CLEVELAND CAVALIERS v. MILWAUKEE BUCKS | | 26:51 | 25 | 9 / 16 | 4 / 7 | 5 / 9 | 2 / 2 | 7 | 2 | 2 | 2 | 0 | 5 | 2 | 36 |
| 2022-01-30 | 115 - 105 | CLEVELAND CAVALIERS @ DETROIT PISTONS | | 18:58 | 8 | 4 / 10 | 4 / 6 | 0 / 4 | 0 / 0 | 5 | 2 | 1 | 1 | 0 | 1 | 3 | 12 |
| 2022-01-31 | 93 - 90 | CLEVELAND CAVALIERS v. NEW ORLEANS PELICANS | | 33:01 | 15 | 6 / 15 | 3 / 7 | 3 / 8 | 0 / 0 | 10 | 1 | 3 | 0 | 2 | 0 | 1 | 18 |
| 2022-02-02 | 115 - 104 | CLEVELAND CAVALIERS @ HOUSTON ROCKETS | | 29:05 | 21 | 8 / 20 | 7 / 13 | 1 / 7 | 4 / 5 | 10 | 3 | 3 | 0 | 1 | 1 | 1 | 24 |
| 2022-02-04 | 101 - 102 | CLEVELAND CAVALIERS @ CHARLOTTE HORNETS | | 25:46 | 25 | 7 / 18 | 1 / 4 | 6 / 14 | 5 / 5 | 8 | 1 | 1 | 0 | 0 | 1 | 3 | 25 |
| 2022-02-06 | 98 - 85 | CLEVELAND CAVALIERS v. INDIANA PACERS | | 32:26 | 19 | 6 / 15 | 2 / 7 | 4 / 8 | 3 / 4 | 4 | 3 | 5 | 2 | 0 | 1 | 2 | 24 |
| 2022-02-09 | 105 - 92 | CLEVELAND CAVALIERS v. SAN ANTONIO SPURS | | 24:18 | 7 | 3 / 13 | 3 / 9 | 0 / 4 | 1 / 4 | 8 | 2 | 1 | 0 | 0 | 2 | 3 | 7 |
| 2022-02-11 | 113 - 120 | CLEVELAND CAVALIERS @ INDIANA PACERS | | 26:20 | 14 | 4 / 8 | 1 / 3 | 3 / 5 | 3 / 4 | 4 | 0 | 1 | 0 | 0 | 1 | 2 | 15 |
| 2022-02-12 | 103 - 93 | CLEVELAND CAVALIERS @ PHILADELPHIA 76ERS | | 17:19 | 2 | 1 / 5 | 1 / 1 | 0 / 4 | 0 / 0 | 2 | 0 | 2 | 0 | 1 | 0 | 0 | 1 |
| 2022-02-15 | 124 - 116 | CLEVELAND CAVALIERS @ ATLANTA HAWKS | | 25:51 | 21 | 7 / 17 | 2 / 5 | 5 / 12 | 2 / 2 | 5 | 2 | 2 | 0 | 0 | 1 | 3 | 21 |
| 2022-02-24 | 106 - 103 | CLEVELAND CAVALIERS @ DETROIT PISTONS | | 16:33 | 4 | 1 / 5 | 0 / 1 | 1 / 4 | 1 / 2 | 5 | 0 | 1 | 0 | 0 | 2 | 2 | 7 |
