| 2021-10-25 | 87 - 99 | CLEVELAND CAVALIERS @ DENVER NUGGETS | * | 31:07 | 9 | 4 / 9 | 3 / 6 | 1 / 3 | 0 / 0 | 2 | 1 | 7 | 1 | 0 | 3 | 1 | 18 |
| 2021-10-27 | 79 - 92 | CLEVELAND CAVALIERS @ LOS ANGELES CLIPPERS | * | 27:58 | 16 | 5 / 8 | 3 / 5 | 2 / 3 | 4 / 4 | 4 | 0 | 6 | 1 | 0 | 6 | 0 | 30 |
| 2021-10-29 | 113 - 101 | CLEVELAND CAVALIERS @ LOS ANGELES LAKERS | * | 32:17 | 18 | 6 / 14 | 3 / 5 | 3 / 9 | 3 / 4 | 1 | 0 | 11 | 1 | 0 | 6 | 0 | 28 |
| 2021-10-30 | 101 - 92 | CLEVELAND CAVALIERS @ PHOENIX SUNS | * | 31:31 | 11 | 5 / 11 | 4 / 6 | 1 / 5 | 0 / 0 | 3 | 0 | 5 | 2 | 1 | 6 | 1 | 20 |
| 2021-11-01 | 110 - 113 | CLEVELAND CAVALIERS @ CHARLOTTE HORNETS | * | 35:07 | 16 | 5 / 13 | 4 / 7 | 1 / 6 | 5 / 7 | 3 | 0 | 4 | 3 | 0 | 3 | 1 | 19 |
| 2021-11-03 | 107 - 104 | CLEVELAND CAVALIERS v. PORTLAND TRAIL BLAZERS | * | 36:23 | 19 | 6 / 9 | 1 / 3 | 5 / 6 | 2 / 2 | 2 | 0 | 10 | 1 | 0 | 3 | 2 | 32 |
| 2021-11-05 | 101 - 102 | CLEVELAND CAVALIERS @ TORONTO RAPTORS | * | 36:23 | 21 | 8 / 12 | 6 / 9 | 2 / 3 | 3 / 3 | 1 | 0 | 8 | 1 | 0 | 4 | 1 | 31 |
| 2021-11-07 | 109 - 126 | CLEVELAND CAVALIERS @ NEW YORK KNICKS | * | 35:17 | 16 | 6 / 14 | 2 / 9 | 4 / 5 | 0 / 0 | 3 | 0 | 5 | 1 | 0 | 3 | 1 | 20 |
| 2021-11-10 | 94 - 97 | CLEVELAND CAVALIERS v. WASHINGTON WIZARDS | * | 36:13 | 19 | 8 / 16 | 5 / 6 | 3 / 10 | 0 / 0 | 1 | 0 | 4 | 1 | 0 | 4 | 2 | 21 |
| 2021-11-12 | 98 - 78 | CLEVELAND CAVALIERS v. DETROIT PISTONS | * | 34:51 | 21 | 8 / 14 | 4 / 5 | 4 / 9 | 1 / 1 | 2 | 0 | 7 | 2 | 0 | 2 | 2 | 28 |
| 2021-11-13 | 91 - 89 | CLEVELAND CAVALIERS v. BOSTON CELTICS | * | 35:53 | 22 | 7 / 15 | 5 / 7 | 2 / 8 | 6 / 6 | 3 | 1 | 6 | 1 | 0 | 3 | 2 | 28 |
| 2021-11-15 | 92 - 98 | CLEVELAND CAVALIERS v. BOSTON CELTICS | * | 34:43 | 17 | 6 / 15 | 3 / 8 | 3 / 7 | 2 / 3 | 1 | 0 | 2 | 1 | 0 | 3 | 2 | 14 |
| 2021-11-18 | 89 - 104 | CLEVELAND CAVALIERS v. GOLDEN STATE WARRIORS | * | 38:01 | 25 | 10 / 22 | 6 / 11 | 4 / 11 | 1 / 1 | 0 | 1 | 5 | 2 | 0 | 7 | 2 | 28 |
| 2021-11-22 | 112 - 117 | CLEVELAND CAVALIERS v. BROOKLYN NETS | * | 38:35 | 24 | 9 / 27 | 7 / 17 | 2 / 10 | 4 / 4 | 3 | 2 | 11 | 0 | 0 | 2 | 3 | 24 |
| 2021-11-24 | 115 - 120 | CLEVELAND CAVALIERS v. PHOENIX SUNS | * | 30:03 | 19 | 8 / 19 | 8 / 13 | 0 / 6 | 3 / 5 | 2 | 1 | 7 | 1 | 0 | 2 | 6 | 19 |
| 2021-11-27 | 105 - 92 | CLEVELAND CAVALIERS v. ORLANDO MAGIC | * | 36:18 | 26 | 11 / 21 | 8 / 14 | 3 / 7 | 1 / 2 | 3 | 1 | 11 | 1 | 0 | 4 | 2 | 35 |
| 2021-11-29 | 96 - 114 | CLEVELAND CAVALIERS @ DALLAS MAVERICKS | * | 32:41 | 18 | 7 / 13 | 6 / 10 | 1 / 3 | 3 / 3 | 2 | 0 | 9 | 0 | 0 | 5 | 3 | 28 |
| 2021-12-01 | 85 - 111 | CLEVELAND CAVALIERS @ MIAMI HEAT | * | 37:19 | 16 | 6 / 13 | 2 / 5 | 4 / 8 | 0 / 0 | 3 | 0 | 7 | 0 | 0 | 5 | 1 | 24 |
| 2021-12-03 | 101 - 116 | CLEVELAND CAVALIERS @ WASHINGTON WIZARDS | * | 34:15 | 32 | 11 / 17 | 6 / 11 | 5 / 6 | 5 / 5 | 7 | 1 | 10 | 1 | 0 | 7 | 6 | 52 |
| 2021-12-05 | 108 - 109 | CLEVELAND CAVALIERS v. UTAH JAZZ | * | 34:31 | 31 | 11 / 19 | 6 / 11 | 5 / 8 | 4 / 4 | 2 | 2 | 5 | 4 | 1 | 4 | 1 | 39 |
| 2021-12-06 | 112 - 104 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | * | 34:30 | 10 | 3 / 12 | 2 / 9 | 1 / 3 | 3 / 3 | 3 | 0 | 9 | 0 | 0 | 4 | 0 | 17 |
| 2021-12-08 | 115 - 92 | CLEVELAND CAVALIERS v. CHICAGO BULLS | * | 32:45 | 24 | 9 / 16 | 6 / 9 | 3 / 7 | 3 / 3 | 3 | 0 | 6 | 1 | 0 | 2 | 3 | 29 |
| 2021-12-10 | 106 - 123 | CLEVELAND CAVALIERS @ MINNESOTA TIMBERWOLVES | * | 31:22 | 12 | 5 / 10 | 3 / 5 | 2 / 5 | 0 / 0 | 2 | 0 | 12 | 1 | 0 | 5 | 2 | 27 |
| 2021-12-11 | 117 - 103 | CLEVELAND CAVALIERS v. SACRAMENTO KINGS | * | 37:25 | 16 | 7 / 17 | 6 / 11 | 1 / 6 | 1 / 1 | 6 | 0 | 13 | 3 | 1 | 5 | 3 | 32 |
| 2021-12-13 | 105 - 94 | CLEVELAND CAVALIERS v. MIAMI HEAT | * | 36:06 | 16 | 5 / 16 | 2 / 9 | 3 / 7 | 3 / 3 | 4 | 0 | 5 | 3 | 0 | 3 | 2 | 20 |
| 2021-12-15 | 124 - 89 | CLEVELAND CAVALIERS v. HOUSTON ROCKETS | * | 25:15 | 21 | 7 / 11 | 4 / 5 | 3 / 6 | 4 / 4 | 1 | 1 | 3 | 0 | 0 | 1 | 1 | 23 |
| 2021-12-18 | 90 - 119 | CLEVELAND CAVALIERS @ MILWAUKEE BUCKS | * | 32:16 | 22 | 10 / 13 | 8 / 9 | 2 / 4 | 0 / 0 | 4 | 0 | 6 | 1 | 0 | 2 | 0 | 32 |
| 2021-12-26 | 144 - 99 | CLEVELAND CAVALIERS v. TORONTO RAPTORS | * | 29:20 | 22 | 9 / 17 | 6 / 8 | 3 / 9 | 1 / 1 | 3 | 1 | 8 | 2 | 0 | 4 | 0 | 32 |
| 2022-01-04 | 106 - 110 | CLEVELAND CAVALIERS v. MEMPHIS GRIZZLIES | * | 35:32 | 27 | 9 / 26 | 6 / 16 | 3 / 10 | 6 / 6 | 1 | 3 | 10 | 0 | 0 | 1 | 1 | 25 |
| 2022-01-07 | 101 - 114 | CLEVELAND CAVALIERS @ PORTLAND TRAIL BLAZERS | * | 38:47 | 26 | 10 / 17 | 5 / 9 | 5 / 8 | 1 / 1 | 1 | 0 | 6 | 1 | 0 | 3 | 1 | 30 |
| 2022-01-09 | 96 - 82 | CLEVELAND CAVALIERS @ GOLDEN STATE WARRIORS | * | 32:53 | 9 | 3 / 12 | 1 / 5 | 2 / 7 | 1 / 2 | 2 | 0 | 4 | 1 | 0 | 4 | 2 | 10 |
| 2022-01-10 | 108 - 109 | CLEVELAND CAVALIERS @ SACRAMENTO KINGS | * | 33:58 | 12 | 5 / 13 | 4 / 7 | 1 / 6 | 1 / 1 | 4 | 1 | 11 | 1 | 0 | 4 | 2 | 25 |
| 2022-01-12 | 91 - 111 | CLEVELAND CAVALIERS @ UTAH JAZZ | * | 34:19 | 11 | 3 / 11 | 2 / 3 | 1 / 8 | 4 / 4 | 10 | 0 | 14 | 1 | 0 | 2 | 4 | 30 |
| 2022-01-14 | 109 - 114 | CLEVELAND CAVALIERS @ SAN ANTONIO SPURS | * | 37:21 | 32 | 11 / 25 | 7 / 17 | 4 / 8 | 6 / 6 | 4 | 0 | 8 | 1 | 1 | 1 | 1 | 31 |
| 2022-01-15 | 102 - 107 | CLEVELAND CAVALIERS @ OKLAHOMA CITY THUNDER | * | 36:37 | 27 | 11 / 20 | 10 / 13 | 1 / 7 | 4 / 4 | 3 | 2 | 18 | 1 | 0 | 2 | 3 | 44 |
| 2022-01-17 | 114 - 107 | CLEVELAND CAVALIERS v. BROOKLYN NETS | * | 36:11 | 22 | 10 / 19 | 8 / 14 | 2 / 5 | 0 / 0 | 4 | 2 | 12 | 2 | 0 | 6 | 1 | 39 |
| 2022-01-22 | 94 - 87 | CLEVELAND CAVALIERS v. OKLAHOMA CITY THUNDER | * | 38:51 | 23 | 9 / 20 | 8 / 16 | 1 / 4 | 4 / 4 | 1 | 0 | 11 | 1 | 0 | 8 | 4 | 33 |
| 2022-01-24 | 95 - 93 | CLEVELAND CAVALIERS v. NEW YORK KNICKS | * | 38:50 | 13 | 6 / 19 | 5 / 13 | 1 / 6 | 0 / 0 | 2 | 0 | 12 | 2 | 0 | 6 | 1 | 22 |
| 2022-01-26 | 115 - 99 | CLEVELAND CAVALIERS v. MILWAUKEE BUCKS | * | 25:56 | 19 | 7 / 12 | 4 / 7 | 3 / 5 | 2 / 3 | 2 | 0 | 8 | 1 | 0 | 1 | 0 | 25 |
| 2022-01-30 | 115 - 105 | CLEVELAND CAVALIERS @ DETROIT PISTONS | * | 35:49 | 24 | 9 / 18 | 4 / 8 | 5 / 10 | 1 / 1 | 4 | 0 | 7 | 0 | 0 | 2 | 1 | 28 |
| 2022-02-09 | 105 - 92 | CLEVELAND CAVALIERS v. SAN ANTONIO SPURS | * | 30:12 | 27 | 12 / 15 | 9 / 12 | 3 / 3 | 0 / 0 | 5 | 0 | 6 | 1 | 0 | 6 | 2 | 42 |
| 2022-02-12 | 103 - 93 | CLEVELAND CAVALIERS @ PHILADELPHIA 76ERS | * | 34:37 | 27 | 11 / 23 | 8 / 17 | 3 / 6 | 2 / 2 | 4 | 0 | 1 | 0 | 0 | 6 | 1 | 26 |
| 2022-02-15 | 124 - 116 | CLEVELAND CAVALIERS @ ATLANTA HAWKS | * | 35:11 | 30 | 12 / 22 | 8 / 12 | 4 / 10 | 2 / 2 | 2 | 0 | 8 | 1 | 1 | 4 | 3 | 34 |
| 2022-03-02 | 98 - 119 | CLEVELAND CAVALIERS v. CHARLOTTE HORNETS | * | 32:58 | 33 | 13 / 22 | 8 / 12 | 5 / 10 | 2 / 4 | 3 | 0 | 4 | 1 | 0 | 7 | 3 | 37 |
| 2022-03-06 | 104 - 96 | CLEVELAND CAVALIERS v. TORONTO RAPTORS | * | 33:46 | 17 | 5 / 12 | 4 / 7 | 1 / 5 | 6 / 6 | 2 | 1 | 10 | 2 | 0 | 7 | 2 | 32 |
| 2022-03-08 | 124 - 127 | CLEVELAND CAVALIERS @ INDIANA PACERS | * | 37:10 | 41 | 14 / 26 | 10 / 17 | 4 / 9 | 9 / 9 | 3 | 2 | 13 | 2 | 0 | 4 | 2 | 53 |
| 2022-03-11 | 117 - 105 | CLEVELAND CAVALIERS @ MIAMI HEAT | * | 36:30 | 24 | 4 / 17 | 3 / 11 | 1 / 6 | 15 / 16 | 1 | 1 | 10 | 1 | 0 | 7 | 4 | 30 |
| 2022-03-16 | 114 - 118 | CLEVELAND CAVALIERS v. PHILADELPHIA 76ERS | * | 37:35 | 22 | 5 / 15 | 4 / 11 | 1 / 4 | 11 / 12 | 3 | 2 | 7 | 1 | 0 | 2 | 0 | 26 |
| 2022-03-24 | 117 - 104 | CLEVELAND CAVALIERS @ TORONTO RAPTORS | * | 38:25 | 18 | 7 / 18 | 6 / 12 | 1 / 6 | 3 / 3 | 2 | 1 | 10 | 0 | 0 | 4 | 1 | 24 |
| 2022-03-30 | 112 - 120 | CLEVELAND CAVALIERS v. DALLAS MAVERICKS | * | 37:00 | 25 | 10 / 17 | 6 / 13 | 4 / 4 | 1 / 2 | 5 | 0 | 10 | 4 | 0 | 4 | 0 | 40 |
