| 2021-10-22 | 112 - 123 | CLEVELAND CAVALIERS v. CHARLOTTE HORNETS | * | 34:33 | 33 | 13 / 21 | 11 / 14 | 2 / 7 | 5 / 5 | 3 | 1 | 1 | 2 | 0 | 3 | 3 | 35 |
| 2021-10-23 | 101 - 95 | CLEVELAND CAVALIERS v. ATLANTA HAWKS | * | 27:30 | 12 | 5 / 14 | 5 / 12 | 0 / 2 | 2 / 4 | 1 | 0 | 5 | 0 | 0 | 3 | 5 | 10 |
| 2021-10-25 | 87 - 99 | CLEVELAND CAVALIERS @ DENVER NUGGETS | * | 24:39 | 14 | 4 / 11 | 1 / 6 | 3 / 5 | 3 / 4 | 3 | 0 | 2 | 0 | 0 | 1 | 3 | 12 |
| 2021-10-27 | 79 - 92 | CLEVELAND CAVALIERS @ LOS ANGELES CLIPPERS | * | 37:31 | 26 | 12 / 20 | 12 / 16 | 0 / 4 | 2 / 3 | 4 | 3 | 1 | 3 | 0 | 5 | 1 | 33 |
| 2021-10-29 | 113 - 101 | CLEVELAND CAVALIERS @ LOS ANGELES LAKERS | * | 31:39 | 9 | 2 / 9 | 2 / 7 | 0 / 2 | 5 / 6 | 2 | 1 | 3 | 2 | 0 | 3 | 3 | 12 |
| 2021-10-30 | 101 - 92 | CLEVELAND CAVALIERS @ PHOENIX SUNS | * | 18:41 | 10 | 4 / 7 | 4 / 5 | 0 / 2 | 2 / 3 | 1 | 0 | 0 | 0 | 0 | 6 | 2 | 13 |
| 2021-11-01 | 110 - 113 | CLEVELAND CAVALIERS @ CHARLOTTE HORNETS | * | 35:34 | 17 | 5 / 17 | 4 / 12 | 1 / 5 | 6 / 8 | 3 | 4 | 2 | 2 | 0 | 2 | 0 | 16 |
| 2021-11-03 | 107 - 104 | CLEVELAND CAVALIERS v. PORTLAND TRAIL BLAZERS | * | 32:38 | 21 | 8 / 13 | 6 / 9 | 2 / 4 | 3 / 3 | 3 | 0 | 2 | 0 | 0 | 5 | 1 | 26 |
| 2021-11-05 | 101 - 102 | CLEVELAND CAVALIERS @ TORONTO RAPTORS | * | 31:50 | 9 | 4 / 18 | 3 / 13 | 1 / 5 | 0 / 0 | 2 | 3 | 2 | 1 | 0 | 2 | 2 | 5 |
| 2021-11-07 | 109 - 126 | CLEVELAND CAVALIERS @ NEW YORK KNICKS | * | 12:31 | 8 | 4 / 8 | 4 / 5 | 0 / 3 | 0 / 0 | 1 | 0 | 4 | 0 | 0 | 0 | 1 | 9 |
