| 2021-12-11 | 82 - 68 | PS KARLSRUHE LIONS v. WIHA PANTHERS SCHWENNINGEN | * | 31:48 | 8 | 2 / 9 | 1 / 2 | 1 / 7 | 3 / 3 | 2 | 0 | 10 | 3 | 2 | 0 | 2 | 14 |
| 2021-12-18 | 109 - 94 | PS KARLSRUHE LIONS v. VFL ASTROSTARS BOCHUM | * | 34:15 | 24 | 9 / 17 | 7 / 12 | 2 / 5 | 4 / 4 | 2 | 1 | 8 | 2 | 4 | 0 | 0 | 25 |
| 2021-12-23 | 91 - 111 | PS KARLSRUHE LIONS @ EHINGEN URSPRING | * | 29:12 | 15 | 6 / 10 | 3 / 5 | 3 / 5 | 0 / 0 | 1 | 0 | 4 | 1 | 3 | 0 | 1 | 14 |
| 2021-12-26 | 87 - 86 | PS KARLSRUHE LIONS v. ROSTOCK SEAWOLVES | * | 30:48 | 16 | 6 / 13 | 2 / 5 | 4 / 8 | 0 / 0 | 3 | 1 | 1 | 0 | 3 | 0 | 1 | 11 |
| 2022-01-02 | 84 - 88 | PS KARLSRUHE LIONS @ ARTLAND DRAGONS | * | 28:37 | 15 | 5 / 8 | 2 / 2 | 3 / 6 | 2 / 2 | 2 | 0 | 4 | 0 | 2 | 0 | 2 | 16 |
| 2022-01-06 | 84 - 96 | PS KARLSRUHE LIONS v. EISBAEREN BREMERHAVEN | * | 31:24 | 15 | 6 / 14 | 5 / 7 | 1 / 7 | 2 / 3 | 2 | 4 | 4 | 0 | 1 | 1 | 1 | 16 |
| 2022-01-08 | 89 - 85 | PS KARLSRUHE LIONS v. SC ITZEHOE EAGLES | * | 37:36 | 21 | 9 / 18 | 8 / 13 | 1 / 5 | 2 / 2 | 2 | 1 | 2 | 4 | 1 | 0 | 1 | 20 |
| 2022-01-14 | 93 - 88 | PS KARLSRUHE LIONS v. PHOENIX HAGEN | * | 27:04 | 4 | 2 / 7 | 2 / 5 | 0 / 2 | 0 / 0 | 1 | 1 | 0 | 0 | 3 | 0 | 4 | -2 |
| 2022-01-16 | 76 - 74 | PS KARLSRUHE LIONS @ KIRCHHEIM KNIGHTS | * | 27:35 | 3 | 1 / 5 | 1 / 3 | 0 / 2 | 1 / 2 | 4 | 0 | 3 | 3 | 0 | 0 | 2 | 8 |
| 2022-01-22 | 94 - 106 | PS KARLSRUHE LIONS v. SCIENCE CITY JENA | * | 23:00 | 7 | 3 / 8 | 2 / 4 | 1 / 4 | 0 / 0 | 0 | 0 | 1 | 0 | 1 | 0 | 2 | 2 |
| 2022-02-09 | 114 - 65 | PS KARLSRUHE LIONS v. EHINGEN URSPRING | * | 19:20 | 8 | 3 / 3 | 1 / 1 | 2 / 2 | 0 / 0 | 1 | 0 | 4 | 2 | 0 | 0 | 0 | 15 |
| 2022-02-19 | 94 - 101 | PS KARLSRUHE LIONS @ EISBAEREN BREMERHAVEN | * | 29:26 | 10 | 4 / 9 | 2 / 3 | 2 / 6 | 0 / 0 | 2 | 1 | 4 | 3 | 3 | 0 | 1 | 12 |
| 2022-03-04 | 81 - 85 | PS KARLSRUHE LIONS @ UNI BASKETS PADERBORN | * | 26:33 | 10 | 5 / 11 | 5 / 8 | 0 / 3 | 0 / 0 | 4 | 1 | 1 | 1 | 1 | 0 | 2 | 10 |
| 2022-03-06 | 88 - 98 | PS KARLSRUHE LIONS v. SC RASTA VECHTA | * | 29:12 | 20 | 8 / 13 | 6 / 7 | 2 / 6 | 2 / 2 | 2 | 0 | 2 | 3 | 0 | 0 | 1 | 22 |
| 2022-03-25 | 85 - 86 | PS KARLSRUHE LIONS v. ARTLAND DRAGONS | * | 23:41 | 8 | 4 / 7 | 4 / 6 | 0 / 1 | 0 / 0 | 2 | 1 | 1 | 0 | 0 | 0 | 2 | 9 |
| 2022-03-27 | 90 - 84 | PS KARLSRUHE LIONS v. NURNBERG FALCONS BC | | 17:17 | 3 | 1 / 3 | 0 / 2 | 1 / 1 | 0 / 0 | 3 | 0 | 1 | 0 | 2 | 0 | 4 | 3 |