| 2022-05-25 | 92 - 89 | NIAGARA RIVER LIONS @ SASKATCHEWAN RATTLERS | * | 36:48 | 34 | 11 / 20 | 8 / 12 | 3 / 8 | 9 / 13 | 7 | 1 | 4 | 0 | 1 | 0 | 2 | 32 |
| 2022-05-27 | 74 - 86 | NIAGARA RIVER LIONS @ EDMONTON STINGERS | * | 31:36 | 22 | 7 / 16 | 7 / 14 | 0 / 2 | 8 / 8 | 5 | 0 | 5 | 2 | 2 | 0 | 2 | 23 |
| 2022-05-31 | 84 - 95 | NIAGARA RIVER LIONS @ GUELPH NIGHTHAWKS | * | 31:46 | 33 | 11 / 16 | 5 / 7 | 6 / 9 | 5 / 6 | 4 | 0 | 6 | 1 | 5 | 0 | 2 | 33 |
| 2022-06-03 | 87 - 62 | NIAGARA RIVER LIONS v. MONTREAL ALLIANCE | * | 29:51 | 14 | 5 / 10 | 5 / 8 | 0 / 2 | 4 / 5 | 2 | 1 | 9 | 2 | 2 | 0 | 2 | 20 |
| 2022-06-06 | 77 - 79 | NIAGARA RIVER LIONS v. EDMONTON STINGERS | * | 31:28 | 13 | 3 / 12 | 3 / 9 | 0 / 3 | 7 / 9 | 1 | 1 | 8 | 1 | 4 | 1 | 2 | 10 |
| 2022-06-10 | 98 - 97 | NIAGARA RIVER LIONS v. NEWFOUNDLAND GROWLERS | * | 29:26 | 21 | 8 / 18 | 7 / 13 | 1 / 5 | 4 / 5 | 1 | 0 | 2 | 2 | 6 | 0 | 3 | 9 |
| 2022-06-12 | 81 - 86 | NIAGARA RIVER LIONS v. SASKATCHEWAN RATTLERS | * | 34:28 | 8 | 4 / 15 | 4 / 12 | 0 / 3 | 0 / 0 | 4 | 0 | 7 | 1 | 5 | 0 | 2 | 4 |
| 2022-06-15 | 64 - 76 | NIAGARA RIVER LIONS @ MONTREAL ALLIANCE | * | 32:28 | 14 | 5 / 9 | 5 / 7 | 0 / 2 | 4 / 4 | 2 | 0 | 3 | 2 | 2 | 0 | 1 | 15 |
| 2022-06-18 | 89 - 78 | NIAGARA RIVER LIONS v. OTTAWA BLACKJACK | * | 29:29 | 16 | 6 / 17 | 6 / 13 | 0 / 4 | 4 / 7 | 3 | 1 | 4 | 2 | 0 | 0 | 4 | 12 |
| 2022-06-21 | 86 - 90 | NIAGARA RIVER LIONS @ OTTAWA BLACKJACK | * | 33:16 | 25 | 9 / 20 | 8 / 17 | 1 / 3 | 6 / 7 | 5 | 1 | 3 | 1 | 3 | 0 | 3 | 20 |
| 2022-07-01 | 92 - 90 | NIAGARA RIVER LIONS @ SASKATCHEWAN RATTLERS | * | 35:29 | 37 | 10 / 21 | 7 / 17 | 3 / 4 | 14 / 16 | 5 | 4 | 4 | 4 | 2 | 0 | 4 | 39 |
| 2022-07-03 | 99 - 102 | NIAGARA RIVER LIONS @ VANCOUVER BANDITS | * | 30:57 | 23 | 8 / 13 | 7 / 12 | 1 / 1 | 6 / 9 | 0 | 0 | 4 | 1 | 1 | 0 | 1 | 19 |
| 2022-07-06 | 97 - 69 | NIAGARA RIVER LIONS v. EDMONTON STINGERS | * | 28:23 | 20 | 5 / 15 | 5 / 13 | 0 / 2 | 10 / 10 | 2 | 0 | 2 | 6 | 5 | 0 | 2 | 15 |
| 2022-07-09 | 101 - 88 | NIAGARA RIVER LIONS v. GUELPH NIGHTHAWKS | * | 35:31 | 25 | 8 / 15 | 7 / 11 | 1 / 4 | 8 / 10 | 3 | 1 | 10 | 2 | 0 | 0 | 4 | 32 |
| 2022-07-15 | 87 - 95 | NIAGARA RIVER LIONS @ NEWFOUNDLAND GROWLERS | * | 29:33 | 33 | 11 / 19 | 9 / 13 | 2 / 6 | 9 / 9 | 2 | 3 | 3 | 3 | 1 | 0 | 1 | 35 |
| 2022-07-17 | 70 - 93 | NIAGARA RIVER LIONS @ SCARBOROUGH SHOOTING STARS | * | 27:47 | 20 | 7 / 22 | 6 / 17 | 1 / 5 | 5 / 5 | 2 | 3 | 2 | 1 | 2 | 0 | 2 | 11 |
| 2022-07-22 | 75 - 86 | NIAGARA RIVER LIONS v. SCARBOROUGH SHOOTING STARS | * | 29:14 | 8 | 2 / 9 | 1 / 6 | 1 / 3 | 3 / 4 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 4 |
| 2022-07-25 | 86 - 95 | NIAGARA RIVER LIONS v. VANCOUVER BANDITS | * | 33:26 | 22 | 7 / 16 | 3 / 7 | 4 / 9 | 4 / 4 | 2 | 0 | 7 | 2 | 5 | 1 | 4 | 20 |
| 2022-07-29 | 73 - 76 | NIAGARA RIVER LIONS v. BRAMPTON HONEY BADGERS | * | 26:48 | 12 | 3 / 8 | 1 / 4 | 2 / 4 | 4 / 4 | 2 | 1 | 2 | 1 | 7 | 0 | 1 | 6 |
| 2022-07-31 | 79 - 83 | NIAGARA RIVER LIONS @ BRAMPTON HONEY BADGERS | * | 34:28 | 21 | 8 / 16 | 7 / 11 | 1 / 5 | 4 / 5 | 8 | 1 | 7 | 5 | 3 | 1 | 4 | 31 |
| 2022-08-06 | 78 - 99 | NIAGARA RIVER LIONS @ GUELPH NIGHTHAWKS | * | 19:11 | 14 | 4 / 10 | 3 / 7 | 1 / 3 | 5 / 7 | 3 | 1 | 2 | 0 | 2 | 1 | 4 | 11 |
| 2022-08-12 | 81 - 93 | NIAGARA RIVER LIONS v. SCARBOROUGH SHOOTING STARS | * | 36:27 | 23 | 6 / 18 | 4 / 14 | 2 / 4 | 9 / 14 | 2 | 4 | 6 | 1 | 1 | 0 | 2 | 18 |
