| 2022-05-25 | 92 - 89 | NIAGARA RIVER LIONS @ SASKATCHEWAN RATTLERS | * | 26:20 | 14 | 5 / 11 | 5 / 6 | 0 / 5 | 4 / 4 | 6 | 1 | 0 | 1 | 0 | 5 | 3 | 21 |
| 2022-05-27 | 74 - 86 | NIAGARA RIVER LIONS @ EDMONTON STINGERS | * | 22:25 | 14 | 6 / 9 | 6 / 7 | 0 / 2 | 2 / 3 | 4 | 1 | 0 | 1 | 2 | 4 | 3 | 18 |
| 2022-05-31 | 84 - 95 | NIAGARA RIVER LIONS @ GUELPH NIGHTHAWKS | * | 14:16 | 0 | 0 / 3 | 0 / 2 | 0 / 1 | 0 / 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | -3 |
| 2022-06-03 | 87 - 62 | NIAGARA RIVER LIONS v. MONTREAL ALLIANCE | * | 18:10 | 10 | 3 / 8 | 1 / 2 | 2 / 6 | 2 / 2 | 4 | 1 | 0 | 0 | 2 | 2 | 5 | 10 |
| 2022-06-06 | 77 - 79 | NIAGARA RIVER LIONS v. EDMONTON STINGERS | * | 29:30 | 5 | 2 / 6 | 2 / 5 | 0 / 1 | 1 / 2 | 8 | 2 | 0 | 0 | 1 | 7 | 3 | 16 |
| 2022-06-10 | 98 - 97 | NIAGARA RIVER LIONS v. NEWFOUNDLAND GROWLERS | * | 23:20 | 7 | 2 / 5 | 2 / 3 | 0 / 2 | 3 / 4 | 2 | 0 | 0 | 1 | 2 | 1 | 3 | 5 |
| 2022-06-12 | 81 - 86 | NIAGARA RIVER LIONS v. SASKATCHEWAN RATTLERS | * | 26:13 | 13 | 6 / 10 | 6 / 9 | 0 / 1 | 1 / 2 | 5 | 1 | 0 | 0 | 0 | 5 | 3 | 19 |
| 2022-06-15 | 64 - 76 | NIAGARA RIVER LIONS @ MONTREAL ALLIANCE | * | 27:17 | 11 | 5 / 8 | 4 / 5 | 1 / 3 | 0 / 0 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 10 |
| 2022-06-18 | 89 - 78 | NIAGARA RIVER LIONS v. OTTAWA BLACKJACK | * | 27:17 | 15 | 5 / 11 | 2 / 5 | 3 / 6 | 2 / 2 | 0 | 1 | 2 | 1 | 0 | 5 | 2 | 18 |
| 2022-06-21 | 86 - 90 | NIAGARA RIVER LIONS @ OTTAWA BLACKJACK | * | 23:25 | 16 | 6 / 8 | 4 / 6 | 2 / 2 | 2 / 2 | 2 | 0 | 0 | 1 | 0 | 3 | 3 | 20 |
| 2022-07-22 | 75 - 86 | NIAGARA RIVER LIONS v. SCARBOROUGH SHOOTING STARS | * | 14:23 | 6 | 2 / 5 | 2 / 3 | 0 / 2 | 2 / 2 | 3 | 0 | 0 | 0 | 1 | 2 | 5 | 7 |
| 2022-07-25 | 86 - 95 | NIAGARA RIVER LIONS v. VANCOUVER BANDITS | * | 20:39 | 10 | 5 / 8 | 5 / 7 | 0 / 1 | 0 / 1 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 11 |
| 2022-07-29 | 73 - 76 | NIAGARA RIVER LIONS v. BRAMPTON HONEY BADGERS | * | 20:27 | 8 | 4 / 7 | 4 / 5 | 0 / 2 | 0 / 0 | 3 | 0 | 0 | 0 | 1 | 5 | 4 | 12 |
| 2022-07-31 | 79 - 83 | NIAGARA RIVER LIONS @ BRAMPTON HONEY BADGERS | * | 10:21 | 4 | 1 / 3 | 1 / 2 | 0 / 1 | 2 / 2 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 5 |
| 2022-08-06 | 78 - 99 | NIAGARA RIVER LIONS @ GUELPH NIGHTHAWKS | * | 26:04 | 28 | 10 / 14 | 5 / 7 | 5 / 7 | 3 / 7 | 4 | 2 | 0 | 0 | 2 | 3 | 4 | 27 |
| 2022-08-12 | 81 - 93 | NIAGARA RIVER LIONS v. SCARBOROUGH SHOOTING STARS | * | 25:47 | 26 | 8 / 10 | 3 / 5 | 5 / 5 | 5 / 6 | 2 | 1 | 0 | 0 | 0 | 2 | 3 | 28 |
